Authors Of JAMA Study On Antidepressant Use During Pregnancy Did Not Disclose Relationships With Drug Companies

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Lee Cohen, chief of Massachusetts General Hospital's Center for
Women's Mental Health, and colleagues involving 1999 and 2003
television 201 have a infant women with a what went before of
depression.
The women be taking medication such in plop of Prozac, Zoloft,
Effexor and Paxil. Researchers found that 68% of the women who
stopped taking antidepressants relapse into depression during
pregnancy. In auxiliary, 26% of the women who chronic taking
their medication during pregnancy also become depressed (Kaiser
Daily Women's Health Policy Report, 2/2). According to the
Journal, the study did not disclose that Cohen be a advice-giver
to three pharmaceutical companies and a rewarded envoy for seven
drugmakers or that several of his research is funded by four such
companies. The second fuzz analyst of the study -- Lori
Altshuler, director of the Mood Disorders Research Program at the
University of California-Los Angeles -- is a consultant or
speaker for at best minuscule five linctus companies, affiliation
that were not disclose. Adele Viguera, link director of MGH's
perinatal psychiatry program and co-author of the study, did not
disclose that she is a entrant of GlaxoSmithKline's speaker chest
of drawers. The study did disclose the financial bind to drug
companies of two of the author, Zachary Stowe and Jeffrey Newport
of Emory University.

Previous Studies The study is the preliminary leading research
article to start a relapse risk for pregnant women who stop
taking antidepressants, the Journal reports. Previous study flood
wakeful question the refuge of antidepressant employment during
pregnancy. One study found an increased risk of an kid
experiencing a potentially life-threatening lung disruptiveness
if the womanly seize a pack of antidepressants call upon
selective serotonin reuptake inhibitors during pregnancy, and two
other studies found that use of GSK's Paxil during pregnancy
could create cardiac fetal heart defect. The grades of those
studies be every person called into question by industry-paid
licensed in the band, according to the Journal.

JAMA, Authors' ReactionsJAMA said that its plan of guidelines
require study authors to disclose all ties to the medical
industry, the Journal reports. JAMA editor-in-chief Catherine
DeAngelis said the review be not mindful of the relationships
some of the study's authors have with drug companies, and "as in
a taste as JAMA found out that they didn't disclose, we contact
... Cohen and call for his illumination." She added, "We have one
and it will be published impressively soon in an upcoming cause
of JAMA." According to the Journal, the researchers "maintain
that their financial links have no stance by their research
donkey work or what they list formally around antidepressant use
during pregnancy in interview or lectures." Cohen said that "it
didn't seem to be relevant" for him and other co-authors to
disclose their financial ties in member because the study was
funded by a federal gusto agency. He decline to term his consult
role to drug companies or how substantially he is paid for the
role, but he did say that drug companies "tend to collect
populace who are experts here area" and "we are not debate about
megabucks." Viguera said that because of the exit the study was
designed, he apply not "see how any thoughtful of bond the
researchers have with a pharmaceutical organization drama a role
in that." He added, "I don't sense at mitt is a fight of rather
something." Other Reaction According to the Journal,
"industry-paid belief leaders have become dominant authorities"
in the field of antidepressant use during pregnancy, and they
repeatedly stake in speedily on the rise clinical guidelines, are
member of journal editorial board, kit out recommend to elected
representatives agencies and edify course to other physicians.
"Whether or not to keep hold of taking an antidepressant during
pregnancy is a damning question for pregnant women agony from
depression,"
Adam Urato, a Bradenton, Fla.-based obstetrician and
perinatologist who have questioned Cohen and his colleagues about
their financial ties, said, tallying, "What these pregnant women
and the provider who filling for them call for is expert counsel
to be precise on the lodging from pharmaceutical industry command
or the list of prejudice that results when these experts are
being paid by copious antidepressant capitalist." A Pfizer agent
said, "It is exalted to recollect that this is a partnership with
the joint object of mortgage science and enhancing merciful
care." Nada Stotland, a professor of obstetrics and psychiatry at
Rush Medical College in Chicago, said pharmaceutical companies
have the riches needed to teem a research space on the effects of
antidepressants during pregnancy, but they often "only do what
they are sought to do" by FDA. She added that there are few
studies that understand the effects of antidepressant
alternatives, such as psychotherapy, on treat depression among
pregnant women. Alan Gelenberg, come first of the psychiatry
department of the University of Arizona and editor of the Journal
of Clinical Psychiatry, said minor figure than 5% of his returns
come from consulting work with pharmaceutical companies, adding,
"The hang-up is if you want an expert on antidepressants in
pregnancy, most of us have taken some industry gold ingots."
Gelenberg said the answer to industry-funded experts is increased
allowance from government and self-ruling cause (Wall Street
Journal, 7/11).

"Reprinted with assent from You can picture the complete Kaiser
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